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Article

Novel dominant negative Smad antagonists to TGFbeta signaling.

Cellular signalling - 1 Jul 2007

Ho Joanne, Chen Hui, Lebrun Jean-Jacques

Abstract excerpt

We previously identified a critical serine/threonine residue within the linker domain of Smad2/3, phosphorylated by the kinase GRK2 which plays a critical role in regulating Smad signaling. To define the mechanism by which GRK2-mediated phosphorylation modifies Smad2/3 behavior at the molecular level, we generated mutant Smads where the GRK2 phosphorylation site was replaced with an aspartic acid (D) to mimic the...

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Source

Identifiers

PMID: 17360157
DOI: 10.1016/j.cellsig.2007.02.001

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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