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Article

Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition.

Pigment cell & melanoma research - 1 Jun 2011

Cohen-Solal Karine A, Merrigan Kim T, Chan Joseph L-K, Goydos James S, Chen Wenjin, Foran David J, Liu Fang, Lasfar Ahmed, Reiss Michael

Abstract excerpt

Melanoma cells are resistant to transforming growth factor-β (TGFβ)-induced cell-cycle arrest. In this study, we investigated a mechanism of resistance involving a regulatory domain, called linker region, in Smad2 and Smad3, main downstream effectors of TGFβ. Melanoma cells in culture and tumor samples exhibited constitutive Smad2 and Smad3 linker phosphorylation. Treatment of melanoma cells with the MEK1/2...

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Identifiers

PMID: 21477078
DOI: 10.1111/j.1755-148X.2011.00858.x
PMCID: PMC3108265

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