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Article

Overexpression of Smad2 reveals its concerted action with Smad4 in regulating TGF-beta-mediated epidermal homeostasis.

Developmental biology - 1 Aug 2001

Ito Y, Sarkar P, Mi Q, Wu N, Bringas P, Liu Y, Reddy S, Maxson R, Deng C, Chai Y

Abstract excerpt

Members of the transforming growth factor-beta (TGF-beta) superfamily are critical regulators for epithelial growth and can alter the differentiation of keratinocytes. Transduction of TGF-beta signaling depends on the phosphorylation and activation of Smad proteins by heteromeric complexes of ligand-specific type I and II receptors. To understand the function of TGF-beta and activin-specific Smad, we generated...

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Source

Identifiers

PMID: 11456453
DOI: 10.1006/dbio.2001.0332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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