Article

Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion

2019-06-04

Abstract excerpt

p21-activated protein kinases (PAKs) are serine/threonine kinases functioning as downstream effectors of the small GTPases Rac1 and Cdc42. Members of the PAK family are overexpressed in human breast cancer, but their role in mammary gland development is not fully explored. Here we examined the functional role of PAK4 in mammary gland development by creating a mouse model of MMTV-Cre driven conditional PAK4 gene de...

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Literature Corpus work: 1551a2ce-58b0-5b93-b6dd-23d47da6b036
DOI: 10.1101/658583

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