Article
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
Immunity - 19 Jun 2009
Beddoe Travis, Chen Zhenjun, Clements Craig S, Ely Lauren K, Bushell Simon R, Vivian Julian P, Kjer-Nielsen Lars, Pang Siew Siew, Dunstone Michelle A, Liu Yu Chih, Macdonald Whitney A, Perugini Matthew A, Wilce Matthew C J, Burrows Scott R, Purcell Anthony W, Tiganis Tony, Bottomley Stephen P, McCluskey James, Rossjohn Jamie
Abstract excerpt
Ligation of the alphabeta T cell receptor (TCR) by a specific peptide-loaded major histocompatibility complex (pMHC) molecule initiates T cell signaling via the CD3 complex. However, the initial events that link antigen recognition to T cell signal transduction remain unclear. Here we show, via fluorescence-based experiments and structural analyses, that MHC-restricted antigen recognition by the alphabeta TCR...
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