Article
Sequence selective formation of 1,N(6)-ethenoadenine in DNA by furan-conjugated probe.
Bioorganic & medicinal chemistry letters - 1 Jul 2009
Kobori Akio, Morita Jumpei, Ikeda Masato, Yamayoshi Asako, Murakami Akira
Abstract excerpt
1,N(6)-Ethenoadenosine derivatives have been applied as fluorescence probes in various fields of biochemistry and molecular biology. We developed a 1,N(6)-ethenoadenosine-forming reaction at a target adenine in DNA duplex and applied it to a mutation diagnosis. Furan-derivatized oligodeoxyribonucleotides were synthesized and fluorescence properties were studied in the presence of complementary strand under...
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