Article
Anthracene based base-discriminating fluorescent oligonucleotide probes for SNPs typing: synthesis and photophysical properties.
Bioorganic & medicinal chemistry - 1 Jan 2008
Saito Yoshio, Motegi Kaori, Bag Subhendu Sekhar, Saito Isao
Abstract excerpt
2- and 9-Anthracenecarboxamide labeled 2'-deoxyuridines were synthesized and their photophysical properties were examined. These oligonucleonucleotide probes are capable of detecting adenine base on a target DNA sequence. It was also found that 2-anthracene based oligonucleotide probe is more efficient than the corresponding 9-anthracene based oligonucleotide in the application for DNA chip based SNP detection,...
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