Article
EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction.
Molecular psychiatry - 1 May 2018
Mielenz D, Reichel M, Jia T, Quinlan E B, Stöckl T, Mettang M, Zilske D, Kirmizi-Alsan E, Schönberger P, Praetner M, Huber S E, Amato D, Schwarz M, Purohit P, Brachs S, Spranger J, Hess A, Büttner C, Ekici A B, Perez-Branguli F, Winner B, Rauschenberger V, Banaschewski T, Bokde A L W, Büchel C, Conrod P J, Desrivières S, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Martinot J-L, Lemaitre H, Nees F, Paus T, Smolka M N, Schambony A, Bäuerle T, Eulenburg V, Alzheimer C, Lourdusamy A, Schumann G, Müller C P
Abstract excerpt
In many societies, the majority of adults regularly consume alcohol. However, only a small proportion develops alcohol addiction. Individuals at risk often show a high sensation-seeking/low-anxiety behavioural phenotype. Here we asked which role EF hand domain containing 2 (EFhd2; Swiprosin-1) plays in the control of alcohol addiction-associated behaviours. EFhd2 knockout (KO) mice drink more alcohol than...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.