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Article

The novel gene tank, a tumor suppressor homolog, regulates ethanol sensitivity in Drosophila.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 May 2013

Devineni Anita V, Eddison Mark, Heberlein Ulrike

Abstract excerpt

In both mammalian and insect models of ethanol intoxication, high doses of ethanol induce motor impairment and eventually sedation. Sensitivity to the sedative effects of ethanol is inversely correlated with risk for alcoholism. However, the genes regulating ethanol sensitivity are largely unknown. Based on a previous genetic screen in Drosophila for ethanol sedation mutants, we identified a novel gene, tank...

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Identifiers

PMID: 23658154
DOI: 10.1523/JNEUROSCI.3695-12.2013
PMCID: PMC3865512

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