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Article

Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors.

Biological psychiatry - 15 Jan 2007

Monteggia Lisa M, Luikart Bryan, Barrot Michel, Theobold David, Malkovska Irena, Nef Serge, Parada Luis F, Nestler Eric J

Abstract excerpt

BACKGROUND: Indirect evidence suggests that loss of brain-derived neurotrophic factor (BDNF) from forebrain regions contributes to an individual's vulnerability for depression, whereas upregulation of BDNF in these regions is suggested to mediate the therapeutic effect of antidepressants. METHODS: We have tested this hypothesis by generating two independent lines of conditional BDNF knockout mice in which the...

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Source

Identifiers

PMID: 16697351
DOI: 10.1016/j.biopsych.2006.03.021

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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