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Article

Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility.

Journal of virology - 1 Aug 2009

Puertas Maria Carmen, Buzón Maria Jose, Artese Anna, Alcaro Stefano, Menendez-Arias Luis, Perno Carlo Federico, Clotet Bonaventura, Ceccherini-Silberstein Francesca, Martinez-Picado Javier

Abstract excerpt

A negative association between polymorphism Leu-214 and type-1 thymidine analogue mutations (TAM1) and a positive association with a clinically favorable virological response to thymidine analogue-based combination antiretroviral therapy have been described. In this study, the impact of Leu-214 on replication capacity and resistance to zidovudine (ZDV) of viruses containing TAM1 or TAM2 was determined. Leu-214...

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Identifiers

PMID: 19457988
DOI: 10.1128/JVI.00487-09
PMCID: PMC2708641

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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