New resistance mutations to nucleoside reverse transcriptase inhibitors at codon 184 of HIV-1 reverse transcriptase (M184L and M184T).

doi:10.1111/cbdd.13378

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Article

New resistance mutations to nucleoside reverse transcriptase inhibitors at codon 184 of HIV-1 reverse transcriptase (M184L and M184T).

Chemical biology & drug design - 1 Jan 2019

Pouga Lydia, Santoro Maria Mercedes, Charpentier Charlotte, Di Carlo Domenico, Romeo Isabella, Artese Anna, Alcaro Stefano, Antinori Andrea, Wirden Marc, Perno Carlo Federico, Ambrosio Francesca Alessandra, Calvez Vincent, Descamps Diane, Marcelin Anne-Geneviève, Ceccherini-Silberstein Francesca, Lambert-Niclot Sidonie

Abstract excerpt

Mutations at HIV-1 reverse transcriptase (RT) codon 184 such as M184V confer resistance to two nucleos(t)ide RT inhibitors (NRTI), lamivudine (3TC) and emtricitabine (FTC). The prevalence of mutations at HIV-1 RT codon 184 was evaluated using three independent RT sequence databases from treatment-experienced (TE) and treatment-naïve (TN) individuals. Data were collected retrospectively from three centers: one in...

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PMID: 30103267
DOI: 10.1111/cbdd.13378

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