Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility.

Journal of virology - 1 Sept 1996

Harrigan P R, Kinghorn I, Bloor S, Kemp S D, Nájera I, Kohli A, Larder B A

Abstract excerpt

Amino acid variation at reverse transcriptase (RT) codon 210 (generally Leu-210 to Trp [L210W], TTG-->TGG) is occasionally detected after the initiation of azidothymidine (AZT) therapy. The impact of this variation on AZT resistance and viral replication was addressed by four different approaches. The frequency and genetic background of the L210W mutation in vivo were assessed by analyzing sera of AZT-naive and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Codon

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to HeLa Cells

Share to Point Mutation

Share to Polymerase Chain Reaction

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 8709214
DOI: 10.1128/JVI.70.9.5930-5934.1996
PMCID: PMC190612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility.PMID 8709214Read ↗

HIV-1 reverse transcriptase codon 215 mutation in plasma RNA: immunologic and virologic responses to zidovudine. The AIDS Clinical Trials Group Study 175 Virology Team.Semantic proximity Read ↗

Switch to unusual amino acids at codon 215 of the human immunodeficiency virus type 1 reverse transcriptase gene in seroconvertors infected with zidovudine-resistant variants.Semantic proximity Read ↗

Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive personsSemantic proximity Read ↗

Amino Acid Substitutions at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Increase Susceptibility to Delavirdine and Impair Virus ReplicationSemantic proximity Read ↗

Effect of the human immunodeficiency virus type 1 reverse transcriptase polymorphism Leu-214 on replication capacity and drug susceptibility.Semantic proximity Read ↗

Fitness Comparison of Thymidine Analog Resistance Pathways in Human Immunodeficiency Virus Type 1Semantic proximity Read ↗

Mutagenic study of codons 74 and 215 of the human immunodeficiency virus type 1 reverse transcriptase, which are significant in nucleoside analog resistance.Semantic proximity Read ↗

Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.Semantic proximity Read ↗

Establishment of new transmissible and drug-sensitive human immunodeficiency virus type 1 wild types due to transmission of nucleoside analogue-resistant virus.Semantic proximity Read ↗

HIV-1 reverse transcriptase codon 215 mutation and clinical outcome in children treated with zidovudine.Semantic proximity Read ↗

Codon 215 Mutations in Human Immunodeficiency Virus–Infected Pregnant WomenSemantic proximity Read ↗

Emergence and clinical relevance of mutations associated with zidovudine resistance in asymptomatic HIV-1 infected patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.