Article
Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility.
Journal of virology - 1 Sept 1996
Harrigan P R, Kinghorn I, Bloor S, Kemp S D, Nájera I, Kohli A, Larder B A
Abstract excerpt
Amino acid variation at reverse transcriptase (RT) codon 210 (generally Leu-210 to Trp [L210W], TTG-->TGG) is occasionally detected after the initiation of azidothymidine (AZT) therapy. The impact of this variation on AZT resistance and viral replication was addressed by four different approaches...
Topics
- Antiviral Agents
- Codon
- Drug Therapy, Combination
- Genetic Variation
- HIV Reverse Transcriptase
- HIV Seropositivity
- HIV-1
- HeLa Cells
- Humans
- Lamivudine
- Point Mutation
- Polymerase Chain Reaction
- RNA-Directed DNA Polymerase
- Reverse Transcriptase Inhibitors
- Virus Replication