Increased multinucleoside drug resistance and decreased replicative capacity of a human immunodeficiency virus type 1 variant with an 8-amino-Acid insert in the reverse transcriptase.

Abstract excerpt

Resistance to antiretroviral drugs is generally conferred by specific amino acid substitutions, rather than insertions or deletions, in reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1). The exception to these findings is the amino acid insertions found in the beta3-beta4 loop of the RT enzyme in response to treatment with nucleoside reverse transcriptase inhibitors. This insert consists...

Topics

• Adult
• Amino Acid Substitution
• Anti-HIV Agents
• Drug Resistance, Multiple, Viral
• Evolution, Molecular
• HIV Infections
• HIV Reverse Transcriptase
• HIV-1
• Humans
• Male
• Molecular Sequence Data
• Mutation
• Recombination, Genetic