Article
An HIV-1 215V mutant shows increased phenotypic resistance to d4T.
Virus research - 1 Aug 2008
Pernas Maria, López-Galíndez Cecilio
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) viruses with C/S/D/E at 215 codon of the reverse transcriptase (RT) have been associated with the T215Y/F HIV-1 resistant viruses transmission to naïve patients. The uncommon T215V mutation was detected in DNA proviral samples of a treatment-naïve patient. Virus T215V was obtained after cloning the patient-RT into a molecular clone. Wild-type (T215) and resistant...
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