Article
HIV-1 reverse transcriptase codon 215 mutation in plasma RNA: immunologic and virologic responses to zidovudine. The AIDS Clinical Trials Group Study 175 Virology Team.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association - 1 Mar 1998
Rey D, Hughes M, Pi J T, Winters M, Merigan T C, Katzenstein D A
Abstract excerpt
Treatment of HIV infection with zidovudine (ZDV) may select for changes in the genetic sequence of the viral reverse transcriptase (RT) that imparts drug resistance. The presence of a 2-bp mutation at codon 215 of RT (from threonine to phenylalanine or tyrosine) was assessed in plasma viral RNA i...
Topics
- Anti-HIV Agents
- CD4 Lymphocyte Count
- Codon
- Drug Resistance, Microbial
- Female
- Genotype
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Male
- Mutation
- RNA, Viral