Article
Impact of HIV-1 reverse transcriptase polymorphism F214L on virological response to thymidine analogue-based regimens in antiretroviral therapy (ART)-naive and ART-experienced patients.
The Journal of infectious diseases - 15 Oct 2007
Ceccherini-Silberstein Francesca, Cozzi-Lepri Alessandro, Ruiz Lidia, Mocroft Amanda, Phillips Andrew N, Olsen Christian Holkmann, Gatell Jose M, Gunthard Huldrych F, Reiss Peter, Perno Carlo Federico, Clotet Bonaventura, Lundgren Jens D
Abstract excerpt
BACKGROUND: A negative association between the polymorphism F214L and type 1 thymidine analogue (TA) mutations (TAMs) has been observed. However, the virological response to TAs according to the detection of F214L has not been evaluated. METHODS: We studied 590 patients from EuroSIDA who started TA therapy for the first time as part of potent combination antiretroviral therapy (cART) and who were tested for...
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