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Article

Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function.

The Journal of biological chemistry - 16 May 2008

Shen Wei-Hua, Chen Zhuang, Shi Shu, Chen Hanying, Zhu Wuqiang, Penner Anne, Bu Guixue, Li Wei, Boyle David W, Rubart Michael, Field Loren J, Abraham Robert, Liechty Edward A, Shou Weinian

Abstract excerpt

Mammalian target of rapamycin (mTOR) is a key regulator for cell growth through modulating components of the translation machinery. Previously, numerous pharmacological studies using rapamycin suggested that mTOR has an important role in regulating cardiac hypertrophic growth. To further investig...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18326485
DOI: 10.1074/jbc.M801510200
PMCID: PMC2376248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18326485-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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