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Article

Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2009

Sanborn Keri B, Rak Gregory D, Maru Saumya Y, Demers Korey, Difeo Analisa, Martignetti John A, Betts Michael R, Favier Rémi, Banerjee Pinaki P, Orange Jordan S

Abstract excerpt

NK cell cytotoxicity requires the formation of an actin-rich immunological synapse (IS) with a target cell and the polarization of perforin-containing lytic granules toward the IS. Following the polarization of lytic granules, they traverse through the actin-rich IS to join the NK cell membrane in order for directed secretion of their contents to occur. We examined the role of myosin IIA as a candidate for...

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Identifiers

PMID: 19454694
DOI: 10.4049/jimmunol.0804337
PMCID: PMC2835774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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