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Article

The secretory synapse: the secrets of a serial killer.

Immunological reviews - 1 Nov 2002

Bossi Giovanna, Trambas Christina, Booth Sarah, Clark Richard, Stinchcombe Jane, Griffiths Gillian M

Abstract excerpt

Cytotoxic T lymphocytes (CTLs) destroy their targets by a process involving secretion of specialized granules. The interactions between CTLs and target can be very brief; nevertheless, adhesion and signaling proteins segregate into an immunological synapse. Secretion occurs in a specialized secretory domain. Use of live and fixed cell microscopy allows this secretory synapse to be visualized both temporally and...

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Share to Cytotoxicity, Immunologic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

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Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 12445272
DOI: 10.1034/j.1600-065x.2002.18913.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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