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Human Immunodeficiency Syndromes Affecting Human Natural Killer Cell Cytolytic Activity

1 Jan 2014

Abstract excerpt

Natural killer (NK) cells are lymphocytes of the innate immune system that secrete cytokines upon activation and mediate the killing of tumor cells and virus-infected cells, especially those that escape the adaptive T cell response caused by the down regulation of MHC-I. The induction of cytotoxicity requires that NK cells contact target cells through adhesion receptors, and initiate activation signaling leading...

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PMID: 24478771
DOI: 10.3389/fimmu.2014.00002

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