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Article

Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis.

The Journal of biological chemistry - 15 Nov 2002

Coppolino Marc G, Dierckman Renee, Loijens Joost, Collins Richard F, Pouladi Mahmoud, Jongstra-Bilen Jenny, Schreiber Alan D, Trimble William S, Anderson Richard, Grinstein Sergio

Abstract excerpt

Actin polymerization drives the extension of pseudopods required for phagocytosis. Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is thought to play a central role in this process, because it interacts with several actin-regulatory proteins and undergoes acute and localized changes at sites of phagocytosis. We therefore studied whether phosphatidylinositol-4-phosphate 5-kinase (PIPK), the enzyme responsible for...

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Identifiers

PMID: 12223494
DOI: 10.1074/jbc.M209046200

Genes

PIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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