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Article

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function

7 Mar 2011

Abstract excerpt

Wiskott-Aldrich syndrome (WAS) is a primary immunodeficiency associated with an increased susceptibility to herpesvirus infection and hematologic malignancy as well as a deficiency of NK cell function. It is caused by defective WAS protein (WASp). WASp facilitates filamentous actin (F-actin) branching and is required for F-actin accumulation at the NK cell immunological synapse and NK cell cytotoxicity ex vivo....

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PMID: 21383498
DOI: 10.1172/jci44862

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