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Article

Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts.

Epilepsia - 1 Jul 2009

Szoeke Cassandra, Sills Graeme J, Kwan Patrick, Petrovski Slave, Newton Mark, Hitiris Nikolas, Baum Larry, Berkovic Samuel F, Brodie Martin J, Sheffield Leslie J, O'Brien Terence J

Abstract excerpt

PURPOSE: The association between a specific polymorphism (3435C>T) in the ABCB1 gene, coding for the membrane drug transporter P-glycoprotein (PgP), and pharmacoresistance to seizure control is controversial. Studies have been limited by multiple drug use, chronic cohorts with varying definitions, and retrospective clinical data. Herein we examine the relationship of this polymorphism with seizure recurrence in...

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Source

Identifiers

PMID: 19453704
DOI: 10.1111/j.1528-1167.2009.02059.x

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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