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Article

Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study.

The Lancet. Neurology - 1 Aug 2006

Leschziner Guy, Jorgensen Andrea L, Andrew Toby, Pirmohamed Munir, Williamson Paula R, Marson Anthony G, Coffey Alison J, Middleditch Claire, Rogers Jane, Bentley David R, Chadwick David W, Balding David J, Johnson Michael R

Abstract excerpt

BACKGROUND: The ABCB1 3435C-->T single-nucleotide polymorphism (SNP) or a three-SNP haplotype containing 3435C-->T has been implicated in multidrug resistance in epilepsy in three retrospective case-control studies, but a further three have failed to replicate the association. We aimed to determine the effect of the ABCB1 gene on epilepsy drug response, using a unique large cohort of epilepsy patients with...

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Share to Anticonvulsants
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16857572
DOI: 10.1016/S1474-4422(06)70500-2

Genes

ABCB1
ABCB4

Provenance

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study.PMID 16857572Read ↗

Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.Semantic proximity Read ↗

The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy.Semantic proximity Read ↗

Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts.Semantic proximity Read ↗

Association of ABCB1 gene polymorphisms and their haplotypes with response to antiepileptic drugs: a systematic review and meta-analysis.Semantic proximity Read ↗

ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-analysis.Semantic proximity Read ↗

Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients.Semantic proximity Read ↗

Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: a meta-analysis.Semantic proximity Read ↗

Genetic factors associated with drug-resistance of epilepsy: relevance of stratification by patient age and aetiology of epilepsy.Semantic proximity Read ↗

Polymorphisms in the Drug Transporter Gene ABCB1 Are Associated with Drug Response in Saudi Epileptic Pediatric PatientsSemantic proximity Read ↗

Complex haplotypic effects of the ABCB1 gene on epilepsy treatment response.Semantic proximity Read ↗

Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy.Semantic proximity Read ↗

The ABCB1-C3435T polymorphism likely acts as a risk factor for resistance to antiepileptic drugs.Semantic proximity Read ↗

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