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Article

ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-analysis.

Seizure - 1 Jul 2010

Haerian B S, Roslan H, Raymond A A, Tan C T, Lim K S, Zulkifli S Z, Mohamed E H M, Tan H J, Mohamed Z

Abstract excerpt

OBJECTIVE: The C3435T, a major allelic variant of the ABCB1 gene, is proposed to play a crucial role in drug-resistance in epilepsy. The C/C genotype carriers reportedly are at higher risk of pharmacoresistance to AEDs, but only in some studies. The hypothesis of the C-variant associated risk and...

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Share to Anticonvulsants
Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20605481
DOI: 10.1016/j.seizure.2010.05.004

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20605481-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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ABCB1 C3435T polymorphism and the risk of resistance to antiepileptic drugs in epilepsy: a systematic review and meta-analysis.PMID 20605481Read ↗

The ABCB1-C3435T polymorphism likely acts as a risk factor for resistance to antiepileptic drugs.Semantic proximity Read ↗

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