Article
Genetic diversity of the Plasmodium vivax multidrug resistance 1 gene in Thai parasite populations.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2018
Kittichai Veerayuth, Nguitragool Wang, Ngassa Mbenda Huguette Gaelle, Sattabongkot Jetsumon, Cui Liwang
Abstract excerpt
Plasmodium vivax resistance to chloroquine (CQ) was first reported over 60 years ago. Here we analyzed sequence variations in the multidrug resistance 1 gene (Pvmdr1), a putative molecular marker for P. vivax CQ resistance, in field isolates collected from three sites in Thailand during 2013-2016. Several single nucleotide polymorphisms previously implicated in reduced CQ sensitivity were found. These genetic...
Topics
- Antimalarials
- Drug Resistance
- Genetic Variation
- Genetics, Population
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Malaria, Vivax
- Monte Carlo Method
- Multidrug Resistance-Associated Proteins
- Parasitic Sensitivity Tests