Article
Chloroquine resistance is associated to multi-copy pvcrt-o gene in Plasmodium vivax malaria in the Brazilian Amazon.
Malaria journal - 16 Jul 2018
Silva Siuhelem Rocha, Almeida Anne Cristine Gomes, da Silva George Allan Villarouco, Ramasawmy Rajendranath, Lopes Stefanie Costa Pinto, Siqueira André Machado, Costa Gabriel Luíz, Sousa Taís Nóbrega, Vieira José Luiz Fernandes, Lacerda Marcus Vinícius Guimarães, Monteiro Wuelton Marcelo, de Melo Gisely Cardoso
Abstract excerpt
BACKGROUND: The resistance of Plasmodium vivax to chloroquine has become an obstacle to control strategies based on the use of anti-malarials. The current study investigated the association between P. vivax CQ-resistance in vivo with copy number variation and mutations in the promoter region in pvcrt-o and pvmdr1 genes. METHODS: The study included patients with P. vivax that received supervised treatment with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.