Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein

19 May 2009

Abstract excerpt

Although flaviviruses cause significant human diseases, no effective therapy is currently available. Host factors essential for viral replication are potential targets for antiviral development. Here we report that cyclophilins (CyPs), a family of cellular peptidyl-prolyl isomerases (PPIases), play a role in flavivirus replication. Huh-7.5 cells with knockdown of different isoforms of CyP were less efficient than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insect Resistance and Genetics
Share to Mosquito-borne diseases and control
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19451286
DOI: 10.1128/aac.00189-09

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 ProteinPMID 19451286Read ↗

Hepatitis E virus genome replication is independent of cyclophilins A and BSemantic proximity Read ↗

Insights into the Roles of Cyclophilin A During Influenza Virus InfectionSemantic proximity Read ↗

Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics.Semantic proximity Read ↗

Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell cultureSemantic proximity Read ↗

Cyclophilin E Functions as a Negative Regulator to Influenza Virus Replication by Impairing the Formation of the Viral Ribonucleoprotein ComplexSemantic proximity Read ↗

Curing a viral infection by targeting the host: The example of cyclophilin inhibitorsSemantic proximity Read ↗

Identification of cellular and viral factors related to anti‐hepatitis C virus activity of cyclophilin inhibitorSemantic proximity Read ↗

Induction of antiviral gene expression by cyclosporine A, but not inhibition of cyclophilin A or B, contributes to its restriction of human coronavirus 229E infection in a lung epithelial cell lineSemantic proximity Read ↗

Cyclosporin A inhibits the replication of diverse coronavirusesSemantic proximity Read ↗

Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A.Semantic proximity Read ↗

Cyclophilin Inhibitors: An Emerging Class of Therapeutics for the Treatment of Chronic Hepatitis C InfectionSemantic proximity Read ↗

Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.