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Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture

15 Dec 2017

Abstract excerpt

Cyclophilin A (CypA) is an important host factor in the replication of a variety of RNA viruses. Also the replication of several nidoviruses was reported to depend on CypA, although possibly not to the same extent. These prior studies are difficult to compare, since different nidoviruses, cell lines and experimental set-ups were used. Here, we investigated the CypA dependence of three distantly related...

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PMID: 29249267
DOI: 10.1016/j.virol.2017.11.022

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