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Insights into the Roles of Cyclophilin A During Influenza Virus Infection

15 Jan 2013

Abstract excerpt

Cyclophilin A (CypA) is the main member of the immunophilin superfamily that has peptidyl-prolyl cis-trans isomerase activity. CypA participates in protein folding, cell signaling, inflammation and tumorigenesis. Further, CypA plays critical roles in the replication of several viruses. Upon influenza virus infection, CypA inhibits viral replication by interacting with the M1 protein. In addition, CypA is...

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PMID: 23322171
DOI: 10.3390/v5010182

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