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Article

Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication.

Current opinion in virology - 1 Oct 2015

von Brunn Albrecht, Ciesek Sandra, von Brunn Brigitte, Carbajo-Lozoya Javier

Abstract excerpt

Replication of coronaviruses is inhibited in vitro by cyclosporin A, a well-known immunosuppressive drug which binds to cellular cyclophilins thus inactivating their enzymatic cis-trans peptidyl-prolyl isomerase function. Latter is required for proper folding of cellular proteins and of proteins of several viruses. Here, we summarize present knowledge on the role of cyclophilin A during coronavirus replication....

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Identifiers

PMID: 26318518
DOI: 10.1016/j.coviro.2015.08.004
PMCID: PMC7102849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication.PMID 26318518Read ↗

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