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Article

Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.

PLoS genetics - 1 Sept 2012

Studencka Maja, Wesołowski Radosław, Opitz Lennart, Salinas-Riester Gabriela, Wisniewski Jacek R, Jedrusik-Bode Monika

Abstract excerpt

Elucidation of the biological role of linker histone (H1) and heterochromatin protein 1 (HP1) in mammals has been difficult owing to the existence of a least 11 distinct H1 and three HP1 subtypes in mice. Caenorhabditis elegans possesses two HP1 homologues (HPL-1 and HPL-2) and eight H1 variants. Remarkably, one of eight H1 variants, HIS-24, is important for C. elegans development. Therefore we decided to analyse...

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PMID: 23028351
DOI: 10.1371/journal.pgen.1002940
PMCID: PMC3441639

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