Article
DNA Methylation Malleability and Dysregulation in Cancer Progression: Understanding the Role of PARP1
8 Mar 2022
Abstract excerpt
Mammalian genomic DNA methylation represents a key epigenetic modification and its dynamic regulation that fine-tunes the gene expression of multiple pathways during development. It maintains the gene expression of one generation of cells; particularly, the mitotic inheritance of gene-expression patterns makes it the key governing mechanism of epigenetic change to the next generation of cells. Convincing evidence...