Metabolic liver cancer: associations of rare and common germline variants in one-carbon metabolism and DNA methylation genes.

doi:10.1093/hmg/ddad099

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Metabolic liver cancer: associations of rare and common germline variants in one-carbon metabolism and DNA methylation genes.

Human molecular genetics - 7 Aug 2023

Antwi Samuel O, Heckman Michael, White Launia, Yan Irene, Sarangi Vivekananda, Lauer Kimberly P, Reddy Joseph, Ahmed Fowsiyo, Veliginti Swathi, Mejías Febres Ellis D, Hatia Rikita I, Chang Ping, Izquierdo-Sanchez Laura, Boix Loreto, Rojas Angela, Banales Jesus M, Reig Maria, Stål Per, Gómez Manuel Romero, Singal Amit G, Li Donghui, Hassan Manal M, Roberts Lewis R, Patel Tushar

Abstract excerpt

Animal studies implicate one-carbon metabolism and DNA methylation genes in hepatocellular carcinoma (HCC) development in the setting of metabolic perturbations. Using human samples, we investigated the associations between common and rare variants in these closely related biochemical pathways and risk for metabolic HCC development in a multicenter international study. We performed targeted exome sequencing of 64...

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Identifiers

PMID: 37369012
DOI: 10.1093/hmg/ddad099
PMCID: PMC10407694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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