Germline Epimutation: A Basis for Epigenetic Disease in Humans

Abstract excerpt

Epigenetic modifications of DNA produce reversible and clonally heritable alterations in transcription state. Errors in the elaborate apparatus of epigenetic silencing possessed by higher eukaryotes can lead to "epimutation," abnormal silencing of a gene. It was supposed that an epimutation in the germline would produce a phenotype equivalent to that resulting from an inactivating germline mutation in the same...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Childhood Cancer Survivors' Quality of Life
• Share to Epigenetics and DNA Methylation
• Share to Genetics and Neurodevelopmental Disorders