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Article

A functional screen for germ line p53 mutations based on transcriptional activation.

Cancer research - 15 Dec 1992

Frebourg T, Barbier N, Kassel J, Ng Y S, Romero P, Friend S H

Abstract excerpt

Germ line p53 mutations represent a genetic predisposition for cancer development. At the present time, their detection requires extensive work and their functional significance must be documented. Therefore, we have designed a simple biological assay which detects functionally significant germ line p53 mutations. This assay is based on the cloning of the patient's p53 complementary DNA into a eukaryotic...

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PMID: 1458490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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