Article
A functional screen for germ line p53 mutations based on transcriptional activation.
Cancer research - 15 Dec 1992
Frebourg T, Barbier N, Kassel J, Ng Y S, Romero P, Friend S H
Abstract excerpt
Germ line p53 mutations represent a genetic predisposition for cancer development. At the present time, their detection requires extensive work and their functional significance must be documented. Therefore, we have designed a simple biological assay which detects functionally significant germ l...
Topics
- Base Sequence
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Plasmids
- Transcriptional Activation