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Article

The probability to initiate X chromosome inactivation is determined by the X to autosomal ratio and X chromosome specific allelic properties.

PloS one - 1 Jan 2009

Monkhorst Kim, de Hoon Bas, Jonkers Iris, Mulugeta Achame Eskeatnaf, Monkhorst Wouter, Hoogerbrugge Jos, Rentmeester Eveline, Westerhoff Hans V, Grosveld Frank, Grootegoed J Anton, Gribnau Joost

Abstract excerpt

BACKGROUND: In female mammalian cells, random X chromosome inactivation (XCI) equalizes the dosage of X-encoded gene products to that in male cells. XCI is a stochastic process, in which each X chromosome has a probability to be inactivated. To obtain more insight in the factors setting up this probability, we studied the role of the X to autosome (X ratio A) ratio in initiation of XCI, and have used the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19440388
DOI: 10.1371/journal.pone.0005616
PMCID: PMC2680018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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