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Article

Choice of random rather than imprinted X inactivation in female embryonic stem cell-derived extra-embryonic cells

10 Dec 2010

Abstract excerpt

In female mammals, one of two X chromosomes is epigenetically inactivated for gene dosage compensation, known as X inactivation (Xi). Inactivation occurs randomly in either the paternal or maternal X chromosome in all embryonic cell lineages, designated as random Xi. By contrast, in extra-embryonic cell lineages, which are segregated from somatic cell lineages in pre-implantation development, the paternal X...

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PMID: 21148183
DOI: 10.1242/dev.056606

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