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Article

Alternative activation in systemic juvenile idiopathic arthritis monocytes.

Clinical immunology (Orlando, Fla.) - 1 Mar 2012

Macaubas Claudia, Nguyen Khoa D, Peck Ariana, Buckingham Julia, Deshpande Chetan, Wong Elizabeth, Alexander Heather C, Chang Sheng-Yung, Begovich Ann, Sun Yue, Park Jane L, Pan Kuang-Hung, Lin Richard, Lih Chih-Jian, Augustine Erin M, Phillips Carolyn, Hadjinicolaou Andreas V, Lee Tzielan, Mellins Elizabeth D

Abstract excerpt

Systemic juvenile idiopathic arthritis (SJIA) is a chronic autoinflammatory condition. The association with macrophage activation syndrome, and the therapeutic efficacy of inhibiting monocyte-derived cytokines, has implicated these cells in SJIA pathogenesis. To characterize the activation state (classical/M1 vs. alternative/M2) of SJIA monocytes, we immunophenotyped monocytes using several approaches. Monocyte...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22281427
DOI: 10.1016/j.clim.2011.12.008
PMCID: PMC3288602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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