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Article

Adaptive two-stage analysis of genetic association in case-control designs.

Human heredity - 1 Jan 2007

Zheng Gang, Song Kijoung, Elston Robert C

Abstract excerpt

We study a two-stage analysis of genetic association for case-control studies. In the first stage, we compare Hardy-Weinberg disequilibrium coefficients between cases and controls and, in the second stage, we apply the Cochran- Armitage trend test. The two analyses are statistically independent when Hardy-Weinberg equilibrium holds in the population, so all the samples are used in both stages. The significance...

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PMID: 17310127
DOI: 10.1159/000099830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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