Article
Detection of M2 macrophages and colony-stimulating factor 1 expression in serous and mucinous ovarian epithelial tumors.
Pathology international - 1 May 2009
Kawamura Kyoko, Komohara Yoshihiro, Takaishi Kiyomi, Katabuchi Hidetaka, Takeya Motohiro
Abstract excerpt
Tumor-associated macrophages (TAM) are known to possess the immunosuppressive M2 macrophage phenotype. They contribute to tumor growth, invasion, and metastasis by producing various mediators. Macrophages, especially M2 polarized macrophages, preferentially express CD163 and CD204, but few studies have investigated macrophage phenotypes in human ovarian tumors. The purpose of the present study was therefore to...
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