Article
Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse.
International journal of cancer - 1 Jan 2014
Reinartz Silke, Schumann Tim, Finkernagel Florian, Wortmann Annika, Jansen Julia M, Meissner Wolfgang, Krause Michael, Schwörer Anne-Marie, Wagner Uwe, Müller-Brüsselbach Sabine, Müller Rolf
Abstract excerpt
Ovarian cancer is typically accompanied by the occurrence of malignant ascites containing large number of macrophages. It has been suggested that these tumor-associated macrophages (TAMs) are skewed to alternative polarization (M2) and thereby play an essential role in therapy resistance and metastatic spread. In our study, we have investigated the nature, regulation and clinical correlations of TAM polarization...
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