Article
Expression of M2-polarized macrophages is associated with poor prognosis for advanced epithelial ovarian cancer.
Technology in cancer research & treatment - 1 Jun 2013
Lan Chunyan, Huang Xin, Lin Suxia, Huang Huiqiang, Cai Qichun, Wan Ting, Lu Jiabin, Liu Jihong
Abstract excerpt
Macrophages are polarized into two functionally distinct forms, M1 and M2, in response to different microenvironment. Tumor-associated macrophages (TAMs) generally have M2 phenotype and promote tumor progression. Few studies to date have described the infiltration of M2-polarized macrophages in ovarian cancer. We used two macrophages markers, CD68 and CD163, to analyze the expression of TAMs and to clarify the...
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