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Article

The distribution of macrophages with a M1 or M2 phenotype in relation to prognosis and the molecular characteristics of colorectal cancer.

PloS one - 1 Jan 2012

Edin Sofia, Wikberg Maria L, Dahlin Anna M, Rutegård Jörgen, Öberg Åke, Oldenborg Per-Arne, Palmqvist Richard

Abstract excerpt

High macrophage infiltration has been correlated to improved survival in colorectal cancer (CRC). Tumor associated macrophages (TAMs) play complex roles in tumorigenesis since they are believed to hold both tumor preventing (M1 macrophages) and tumor promoting (M2 macrophages) activities. Here we have applied an immunohistochemical approach to determine the degree of infiltrating macrophages with a M1 or M2...

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Identifiers

PMID: 23077543
DOI: 10.1371/journal.pone.0047045
PMCID: PMC3471949

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NOS2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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