Article
Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2006
Owen Ryan P, Lagpacan Leah L, Taylor Travis R, De La Cruz Melanie, Huang Conrad C, Kawamoto Michiko, Johns Susan J, Stryke Doug, Ferrin Thomas E, Giacomini Kathleen M
Abstract excerpt
The equilibrative nucleoside transporter 2 (ENT2; SLC29A2) is a bidirectional transporter that is involved in the disposition of naturally occurring nucleosides as well as a variety of anticancer and antiviral nucleoside analogs. The goal of the current study was to evaluate the function of genetic variants in ENT2 in cellular assays and to determine the haplotype structure of the coding and flanking intronic...
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