Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage.

Abstract excerpt

The bone marrow of old adult mice ( approximately 2 years old) has reduced B lymphopoiesis; however, whether the B1 pathway in adult bone marrow is also compromised in senescence is not known. Herein, we show that phenotypic (IgM(-)Lin(-)CD93(+)[AA4.1(+)] CD19(+)B220(low/-)) B1 progenitors are retained in old bone marrow even as B2 B cell precursors are reduced. Moreover, B1 progenitors from both young adult and...

Topics

• Age Factors
• Aging
• Animals
• Antigens, CD19
• Bone Marrow Cells
• Cell Proliferation
• Cells, Cultured
• Cellular Senescence
• Immunoglobulin Light Chains
• Immunoglobulin Light Chains, Surrogate
• Immunoglobulin kappa-Chains
• Immunoglobulin lambda-Chains
• Immunophenotyping