Bcmd decreases the life span of B-2 but not B-1 cells in A/WySnJ mice.

Abstract excerpt

Peripheral B cells are divided into two subpopulations, B-1 and B-2, the relationship of which remains obscure. We recently showed that the Bcmd mutation in A/WySnJ mice reduces average B cell life span, yielding 90% fewer peripheral B cells. Despite this defect, A/WySnJ mice have an elevated proportion of peritoneal CD5+ B cells, suggesting that Bcmd may be the first B-cell-intrinsic gene to differentially...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antigens, CD
• Share to Cell Differentiation
• Share to Flow Cytometry