Article
Identification of a B-1 B cell-specified progenitor.
Nature immunology - 1 Mar 2006
Montecino-Rodriguez Encarnacion, Leathers Hyosuk, Dorshkind Kenneth
Abstract excerpt
The B-1 subpopulation of B lymphocytes differs phenotypically and functionally from conventional B-2 B cells. B-1 B cells are proposed to derive from a distinct progenitor, but such a population has not been isolated. Here we identify and characterize a B-1 B cell progenitor whose numbers peaked in fetal bone marrow but were less abundant in postnatal bone marrow. These Lin(-)CD45R(lo-neg)CD19(+) cells responded...
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