Article
Identification of the earliest B lineage stage in mouse bone marrow.
Immunity - 1 Dec 1996
Li Y S, Wasserman R, Hayakawa K, Hardy R R
Abstract excerpt
We have identified a very early stage of B lineage cells in the CD45R (B220)+CD24 (HSA) pre-pro-B fraction of mouse bone marrow delineated by expression of AA4.1, a molecule found on stem cells and early B lineage cells. These cells are B lineage precursors based on their capacity to generate B lineage cells rapidly in stromal-dependent culture and their expression of high levels of germline IgH transcripts in...
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